Alejandro Tabilo continued his undefeated record against the Serbian, defeating the 38-year-old.
Tabilo secured his place in the third round, where he will face Grigor Dimitrov, with a 6-3, 6-4 triumph.
Djokovic has lost six times this season and hasn't taken home a championship since winning the Olympics in August 2024.
In 2025, Novak Djokovic is still having trouble producing outcomes and reliable performances.
The Serbian has now dropped six games this season and is failed to claim a championship.
Since he became an Olympic champion and has since won every major tennis championship, there has been discussion about his level of drive to play the game.
Given his high expectations for himself, Djokovic is evaluated based on his capacity to win the major titles; yet, Andy Roddick believes the 24-time Grand Slam winner is considering his current status.
He stated that he no longer believes that winning two majors is the baseline for a successful year for Novak. Instead, he emphasized the importance of building up his season, peaking for the majors, and achieving the same level of performance as he had in the past, suggesting that these factors matter more.
Tabilo, who defeated Djokovic in straight sets in the 2024 Italian Open, was the opponent Djokovic faced to start his Monte Carlo campaign.
However, he struggled against Tabilo once more, losing in straight sets after making 14 unforced mistakes in the opening set.
After the game, the world number five apologized to everyone who had witnessed his performance since he was so disappointed with it. However, Roddick does not believe Djokovic should be alarmed by this outcome.
He went on to say that if Novak hadn't lived close by, he wasn't sure whether he would have attended this event or even been there in recent years.
He suggested that the event was almost like paid practice for Novak, who would reset and continue training in Monte Carlo for the clay court season the following Monday.
Although he acknowledged that there might be a matchup issue, he also stated that he didn't place much weight on the current situation and that he would still pick Novak to win three out of five sets if he had a strong run at the French Open for three or four weeks, even after losing to Tabilo twice.