There will be two intriguing domestic rivalries in the Champions League final 16 after Friday's draw ceremony in Nyon, Switzerland.
There is an all-Spanish match between holders Real Madrid and local rivals Atletico Madrid, and an all-German match between Bayern Munich and the defending Bundesliga champions Bayer Leverkusen.
In the playoff round, Madrid crushed Manchester City 6-3 to secure their place in the draw.
In the second leg of their match against Pep Guardiola's team, Real Madrid defeated them 3–1 thanks to a spectacular hat trick from Kylian Mbappe. This was the first time since 2012 that Real Madrid had missed the round of 16.
The European rivalry between Real and Atletico is renewed after the two teams tied 1-1 in La Liga earlier this month. Six Champions League meetings have taken place between the teams, including the 2014 final, which Real Madrid won 4-1 in extra time.
6-Only Chelsea-Liverpool (10) has played the @ChampionsLeague more times than Real Madrid and Atletico de Madrid, who have faced each other six times.
Liverpool, the Premier League's top team, has been paired with Paris Saint-Germain, the French champions. Arsenal and Aston Villa, two other Premier League championship contenders, will play PSV Eindhoven and Club Brugge, respectively.
Liverpool will face PSG for the first time since the 2018-19 season, in which the club claimed their sixth European Championship title.
The Reds need to defeat the dominant Ligue 1 leaders in order to advance, after winning seven of their eight games to lead the league portion of the campaign.
They first met in the semi-finals of the 1997 European Cup Winners' Cup, when PSG defeated Barcelona in the final despite winning 3-2 overall.
If Liverpool defeats Luis Enrique's team, they may play their home rivals, Villa, in the quarterfinals. On Wednesday night, the two teams fought to an intriguing 2-2 tie.
In order to secure their place in the knockout stages, Villa must first overcome surprise package Club Brugge, whom they lost to in the league round. This was one of just two losses Unai Emery's team experienced.
Arsenal will play the victor of the Real Madrid derby against Atletico in the round of eight if they defeat PSV.
Barcelona will play Benfica in another match, and Feyenoord will play their city rivals Inter Milan as a prize for eliminating AC Milan.
Borussia Dortmund, last year's defeated finalists, will face Lille, a French team.